Fig. 5

SUN11602 administration preserved α-Synuclein accumulation. MPTP-intoxicated showed an increase in the number of α-syn aggregates in dopaminergic neurons (B, B1, score F), compared to the Sham group (A, A1, score F). The neuroprotective role of SUN11602, at doses of 2.5 mg/kg and 5 mg/kg, in MPTP-injected mice is revealed by the reduction in the number of α-syn aggregates (D, D1 and E, E1, score F). SUN11602 1 mg/kg was ineffective in diminishing α-Synuclein accumulation (C, C1, score F). Concordant results were also obtained from ELISA analysis of p-α-syn (G). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. *** p < 0.001 vs Sham; # p < 0.05 vs MPTP; ### p < 0.001 vs MPTP