Fig. 8

Effect of SUN11602 on neurons architecture and calcium homeostasis following MPTP injection. MPTP-injected mice showed an important decrease of Calbindin expression compared to the Sham group; while SUN11602 induced a significant upregulation of Calbindin (A, densitometric analysis A1). S-100β and Calpain levels were increased in MPTP-intoxicated mice, however, SUN11602 administration was able to reduce their levels (B, densitometric analysis B1, C). MPTP-intoxicated mice exposed low expression of MAP-2 (E, E1, score G) compared to the Sham group (D, D1, score G). SUN11602 5 mg/kg was able to restore the levels of MAP-2 protein (F, F1, score G). MPTP-injured mice exposed an increase of β3-tubulin-positive cells (I, score K) compared to the Sham animals (H, score K), SUN11602 5 mg/kg administration decreased the non-physiological β3-tubulin expression (J, score K). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; ^##p < 0.01 vs MPTP; ^###p < 0.001 vs MPTP