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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice

Fig. 7

Colocalization of astrocytes with hippocampal vessels. A Confocal microscopic images of hippocampal sections marked with anti-IB4 for endothelium (orange), anti-GFAP (green) for astrocytes and DAPI (blue) for wild-type (WT) and TLR4-mut mice fed a normolipid diet (white bars) or a high-fat diet (black bars) for 24 weeks. The enlarged images show examples of contact between the immunoreactive astrocytic processes and IB4 of the vessel. Magnification: 400x, scale bar 50 µm and 10 µm in depicted pictures. B Graphical representation of the colocalization of GFAP/IB4 *p < 0.05 versus WT-ND ##p < 0.01 vs. WT-HFD. n = 5

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