Association of inflammatory markers with cerebral small vessel disease in community-based population

Table 2 The NRI and IDI estimate of NC, NLR and SII

NC neutrophil count, NLR neutrophil-to-lymphocyte ratio, SII systemic immune-inflammation index (platelet count × neutrophil count/lymphocyte count), NRI net reclassification index, IDI integrated discrimination improvement
*Wardlaw: 1 point allocated for presence of lacunes, microbleeds, moderate-to-severe (> 10) perivascular space in basal ganglia, periventricular white matter hyperintensities Fazekas 3 or deep white matter hyperintensities Fazekas 2–3
^†Rothwell: 1 point allocated for presence of lacunes, 1–4 microbleeds, frequent to severe (> 20) perivascular space in basal ganglia, moderate white matter hyperintensities (total periventricular + subcortical white matter hyperintensities grade 3–4), 2 points allocated for ≥ 5 microbleeds and severe white matter hyperintensities (total periventricular + subcortical white matter hyperintensities grade 5–6)
Basic model: multivariable logistic regression model included age, sex, body mass index, diabetes, hypertension, total cholesterol, high-density lipoprotein, low-density lipoprotein, fasting blood glucose, homocysteine, previous dyslipidemia, previous heart disease, current smoking, current drinking, previous antiplatelet, anticoagulant, antihypertensive, antidiabetic, lipid-lowing drugs use

ISSN: 1742-2094