Fig. 1

ACP cystic fluid caused growth retardation and increased the obesity index in mice. A Eight weeks after surgery, the phenotypes of the 3 groups of mice were assessed. B A graph of average food intake after surgery. Mice in the cystic fluid group showed increased food intake in the early stage after surgery. C A graph of the average water intake after surgery. There was no difference in the amount of water consumed by the three groups of mice. D A graph showing the body weight change after the operation. The weight gain of mice in the cystic fluid group was faster at the initial stage after surgery and then became slower. After 8 weeks, their body weight was smaller than that of the sham-operated group and the control group. E Curve chart of body length change after surgery. The average body length of mice in the cystic fluid group hardly increased within 8 weeks after surgery. F There was no difference in the initial obesity index (Lee index) of the three groups of mice. The obesity index of the mice in the cystic fluid group was higher than that of the sham operation group and the control group at 8 weeks after surgery (P < 0.001). G-H. Eight weeks after surgery, the plasma GHRH and GH levels of mice in the cystic fluid group were lower than those in the sham operation group and the control group (P < 0.05). Control: N = 8, sham: N = 8, cystic fluid: N = 8