Fig. 7
IL-13 mainly exerts neuroprotective effects by inhibiting the phosphorylation of STAT3. A Sensorimotor function was assessed by the adhesive removal test Aa and the foot fault test Ab up to 35d after tMCAO or sham operation. n = 6 mice for Sham + Veh and Sham + IL-13; n = 16 mice for tMCAO + Veh and tMCAO + IL-13; n = 12 mice for tMCAO + stattic; n = 11 mice for tMCAO + stattic + IL-13. B Long-term cognitive function was assessed by the MWM 30–35d after tMCAO or sham operation. Ba Representative swim paths. Bb Latency to find the hidden platform. Bc Time spent in the goal quadrant. n = 6 mice for Sham + Veh and Sham + IL-13; n = 15 mice for tMCAO + Veh and tMCAO + IL-13; n = 12 mice for tMCAO + stattic; n = 11 mice for tMCAO + stattic + IL-13. C Brain tissue loss 35d after tMCAO. Ca Representative images of NeuN (green) immunostaining. Cb, c Quantification of neuronal tissue loss. n = 7–8/groups. All data are presented as the mean ± SEM. *p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. Two-way ANOVA followed by Bonferroni’s post hoc (A, Bb, Cb, c), one-way ANOVA followed by Bonferroni’s post hoc (Bc), Unpaired Student’s t-test (Cb), and Kruskal–Wallis test followed by Dunn’s post hoc (Cc)