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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people

Fig. 4

Graphical representation of the role of CNS neuroinflammation, in NPS, functional cognitive decline and regional brain atrophy. Significant associations or interactions are represented by arrows with standardized coefficients indicated alongside. The dashed arrow represents the interaction of sICAM-1 on the association between AD pathology and NPS. The dotted line represents an association demonstrated in a previous study [19]. Associations between neuroinflammation and NPS are described in detail in Fig. 1 and are independent of BBB function and cognitive status. *P value < 0.05; **P value < 0.01; ***P value < 0.001; C-reactive protein; IP-10, 10-kDa IFN-γ induced protein; sICAM-1, soluble intracellular adhesion molecule-1; A, correlation coefficient

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Journal of Neuroinflammation

ISSN: 1742-2094