Fig. 7
From: Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system
Model for SBNO2 as a negative feedback regulator in the transcriptional response to IL-6. In WT cells, IL-6 stimulates the expression of certain genes (black line, right) including Sbno2. The production of SBNO2 protein (green line, right) contributes to the reduction in expression of some of these genes post-stimulation. In Sbno2−/− cells, the absence of SBNO2 (dashed outline, left) results in heightened and prolonged expression (orange line, right), increasing the intensity of associated IL-6-driven biological processes and, in the GFAP-IL6 × Sbno2−/− cerebellum, subsequent neuropathology (left). Temporal regulation of SBNO2 protein adapted from [27]