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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn

Fig. 2

Activating the LC:SC reduces hyperalgesia in CCI mice. A Experimental protocol for AAV injection and pain threshold test. i.t. intrathecal injection. i.p. intraperitoneal injection. B Schematic representation of the Gq-DREADD protocol targeting LC neurons before pain threshold evaluation. C Changes of mechanical pain threshold in mice after surgery. D Changes of thermal nociceptive threshold in mice after surgery. E Paw withdrawal threshold tested with von Frey filaments decreased in CCI + M3 + Saline group, CCI + Vector + CNO + Yohimbine group, and CCI + Vector + CNO group, compared with the CCI + M3 + CNO group. F Thermal withdrawal latency measured by a plantar thermal testing apparatus reduced in CCI + M3 + Saline group, CCI + Vector + CNO + Yohimbine group, and CCI + Vector + CNO group, compared with the CCI + M3 + CNO group. Data are expressed as mean + SEM, n = 8 for mechanical withdrawal threshold tests and thermal withdrawal latency tests. **p < 0.01, ***p < 0.001, ns not statistically significant

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Journal of Neuroinflammation

ISSN: 1742-2094