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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration

Fig. 3

DRG macrophage accumulation and activation is unaffected in the DRG-targeted ACKOs and DCKOs 7 days after injury. A–H Representative images showing macrophages marked by anti-CD68 in L4 DRGs ipsilateral (B, D, F, H) and contralateral (A, C, E, G) to a sciatic nerve transection. All genotypes have an increase in macrophages after injury (A vs. B; C vs. D; E vs. F; and G vs. H) and no differences in macrophages among genotypes either before (A, C, E, G) or after (B, D, F, H) injury. Scale bar is 50 μm. I Macrophages were quantified as the percent area stained by anti-CD68 and plotted as mean ± SEM, n = 10 per group. # Indicates a significant (p < 0.05) difference between Sh and Ax within a genotype

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Journal of Neuroinflammation

ISSN: 1742-2094