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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

Fig. 3

Acp5 expression in the neuropathic pain/depression comorbidity rats. A Volcano plots of the changed genes from the GEO database (GSE91396). B, C From 6 significant GO terms, seven target genes associated with inflammation were selected. D mRNA levels of S100a9, Ltf, Slip, Cd244, Acp5, Areg and Six1 were explored in PrL in comorbidity rats (n = 3 in each group, unpaired t-test, *p = 0.0342 versus the sham group). E Protein levels of Acp5 was measured in sham group and comorbid group (n = 3 or 6 in each group, unpaired t-test, **p = 0.0033 versus the sham group). F Immunofluorescence staining of Acp5 (red) colocalized with NeuN (neuron marker, green) but not with GFAP (astrocyte marker, green) or Iba1 (microglial marker, green) (n = 2). Data are expressed as mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094