Table 1 PVMs hallmarks identified in the brain of rodents
From: Perivascular macrophages in high-fat diet-induced hypothalamic inflammation
Genes | Cells and brain regions | References |
|---|---|---|
Lyl1, Spic, Mrc1 and Lyve1 | Whole tissue from primary somatosensory cortex (S1) and hippocampal CA1 region | Zeisel et al. 2015 [67] |
Mrc1 and Cd36 | Microglia and PVMs from the brain cortex (without meninges and ChP) | Goldmann et al. 2016 [16] |
ApoE, Ms4a7, Slc2a5, and Sall1 | Microglia and bone marrow-derived parenchymal CNS macrophages of whole brain from bone marrow chimeras | Shemer et al. 2018 [66] |
Downregulation of Lyve1, Cbr2, Folr2, Ccl8, Ctsd, Cd163, F13a1 and H2-Eb1; and upregulation of Cd74, Ccl5, Ciita, H2-Aa, H2-Ab1 and Plbd1 | CD45 + cells isolated from leptomeninges, perivascular space and parenchyma, and ChP from an EAE mouse model | Jordão et al. 2019 [68] |