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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice

Fig. 6

FIR light promoted microglial ATP production mainly through mitochondrial OXPHOS pathway. A Upon the 2-DG pretreatment, Aβ phagocytosis of microglia treated with FIR light or not (n = 6). B Upon the antimycin A pretreatment, Aβ phagocytosis of microglia treated with FIR light or not (n = 6). C Upon the 2-DG plus antimycin A pretreatment, Aβ phagocytosis of microglia treated with FIR light or not (n = 6). D The lactate level of microglia treated with FIR light or not (n = 6). The enzymatic activity of E complex I, F complex II, G complex III, H complex IV, and I ATP synthase in the mitochondrial respiratory chain in BV2 microglia (n = 6). J The NAD+ level and K the ratio of NAD+/NADH of BV2 microglia treated with FIR light or not (n = 9). Data were means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001. N.S.: not significant. AA: antimycin A

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Journal of Neuroinflammation

ISSN: 1742-2094