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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice

Fig. 4

The continuous feeding of ABX alleviates chemotherapy (OXA)-induced mechanical allodynia. OXA treatment itself did not induced significant alteration of thermal sensitivity. A–C Pre-depletion of gut microbiota, two weeks earlier than OXA treatment. D–F The continuous feeding of ABX starting simultaneously with OXA treatment. G–I The continuous feeding of ABX starting two weeks after OXA treatment when the mechanical allodynia had been established. Two-way ANOVA with Sidak multiple comparison test. **p < 0.01, SPF + OXA versus ABX + OXA. Numbers of animals: n = 11 in SPF + OXA; n = 10 in ABX + OXA)

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Journal of Neuroinflammation

ISSN: 1742-2094