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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor

Fig. 7

Proposed molecular mechanism underlying PNDs. Surgical trauma induces transient neuroinflammation by triggering the systemic inflammatory response. Then neuroinflammation causes long-lasting downregulation of synaptic NR2A and NR2B subunits in the dorsal hippocampus that is associated with synaptic NR2A and NR2B dysfunction, which is manifested by impaired structural plasticity of dendritic spine and decreased activated Rac1 (Rac1–GTP), phospho-cofilin, and Arp3 protein expressions. Ultimately, the persistent hypofunction of NR2A and NR2B leads to the development of long-lasting PNDs

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Journal of Neuroinflammation

ISSN: 1742-2094