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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integrity

Fig. 7

dBET1 attenuates ischemia-induced dysregulation of cellular adhesion molecule ICAM-1. A Representative images of endothelial intercellular adhesion molecule 1 (ICAM-1) of the post-stroke mouse brains at 48 h after tMCAO; and open squares indicate the ipsilateral (Ipsil) peri-infarct cortex and striatum areas and corresponding contralateral (Ctrl) areas for micrographic examination (B). C Quantifications of ICAM-1 signals intensity in B. dBET1 reduced ischemia-induced prominent increase of ICAM-1 expression level in either cortex or striatum of the ischemic hemisphere. n = 6 per group. **P < 0.01, ***P < 0.001. D Representative real-time PCR for ICAM-1 mRNA level in the ischemic cortex and sham controls. n = 5 per sham group, n = 6 veh-stroke group, n = 8 dBET1-stroke group. **P < 0.01. E Representative western blots for ICAM-1 level in the ischemic cortex and sham controls. dBET1 significantly attenuated ischemia-induced ICAM-1 upregulation in mRAN and protein levels compared to the corresponding veh controls. n = 5 per sham group, n = 6 per stroke group. **P < 0.01, ***P < 0.001.

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Journal of Neuroinflammation

ISSN: 1742-2094