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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro

Fig. 5

CXCR2 promotes inflammatory cytokine secretion of monocytes and enhanced monocyte-mediated immunogenic cell death (ICD) of neural cells. A mRNA levels of cytokines in peripheral CD14 + monocytes isolated from TBI (T1–T3) or non-TBI (N1–N3) patients. The mRNA level of each cytokine in monocytes of T1 is set as 1.0, and the levels in other patients are presented as the fold change of T1. Red indicates expression higher than T1 and blue indicates expression lower than T1. B Levels of IL-1β, TNFα, and IL-10 secreted by peripheral monocytes isolated from healthy volunteers and educated by serum of TBI/non-TBI patients. *P < 0.05, **P < 0.01, determined by Mann–Whitney tests. (C) Levels of IL-1β, TNFα, and IL-10 secreted by peripheral monocytes isolated from healthy volunteers, pretreated by DMSO (vehicle control) or SB225002, and educated by serum of TBI/non-TBI patients. The grey dots represent monocytes without lipopolysaccharide (LPS) stimulation and the black dots represent monocytes with LPS stimulation. *P < 0.05, **P < 0.01, determined by paired t tests. Data are presented as mean with SEM

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Journal of Neuroinflammation

ISSN: 1742-2094