Fig. 4
From: Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Reduced cholesterol biosynthesis-associated genes in the ArcticC5aR1KO hippocampus. A Heatmap of selected genes in the hippocampus present in RNA cluster 7. Genes were clustered based on biological processes and molecular functions. RNA-seq data (TPM) is row-mean normalized. B Gene ontology (GO) and pathway enrichment analyses of genes present in Rc7. C Representative diagram of the cholesterol biosynthesis pathway with genes present in the panel A heatmap highlighted in red. N = 4–10 mice/genotype/age