Fig. 12

VCE-004.8 reduces apoptosis and neuronal death induced by TBI. A, C Representative confocal images showing NeuN (red) and Tunel (green) expression in pericontusional cortex at 24 h and 72 h after the brain injury. Scale bars equivalent to 100 µm (B–D). B, D The quantification of each marker is shown as mean ± SEM, and significance was determined by one-way ANOVA followed by the Tukey’s post hoc test. B (24 h: p = 0.0119; *p < 0.05, 72 h: p = 0.0014; **p < 0.01 CCI + Vehicle vs Sham, 24 h: p = 0.0010; ##p < 0.01, 72 h: p = 0.0009; ###p < 0.001 CCI + VCE-004.8 vs CCI + Vehicle). D (24 h: p = 0.0006; ***p < 0.001, 72 h: p < 0.0001; ***p < 0.001 CCI + Vehicle vs Sham, 24 h: p = 0.0133; #p < 0.05, 72 h: p < 0.0001; ###p < 0.001 CCI + VCE-004.8 vs CCI + Vehicle)