Table 5 Prediction of key miRNAs target genes and pathways involved
MiRNA | No. of genes | Target genes | KEGG pathways |
|---|---|---|---|
miR-375-3p | 86 | Atpaf1, Cacnb4, Cstf2, Foxe1, Fzd8, Golph3, Otud7b, Pax6, Ube3a, Ywhaz | mRNA surveillance pathway |
miR-449a-5p | 45 | Fam45a, Gmppb, Hdac1, Lrrc59, Lrtm2, Ltbp2, Notch1, Pde1c, Plcb1, Plod1 | Thyroid hormone signaling pathway Adrenergic signaling in cardiomyocytes |
miR-547-3p | 172 | Adcy2, Ap1s3, Cdh2, Igf1、Kitlg, Map4k4, Pdgfrb、Rptor, Smad2, Ube2h | Pathways in cancer PI3K–Akt signaling pathway Rap1 signaling pathway TGF-beta signaling pathway Ubiquitin-mediated proteolysis Signaling pathways regulating, pluripotency of stem cell Central carbon metabolism in cancer |