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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model

Fig. 6

Foxy-5 potentiates nociceptive sensation, while miR-26a-5p rescues this effect. A Experimental design and treatment at different timepoints. B 50% paw withdraw threshold (PWT) of left hind paw of different treatment groups mice. At the day of 10, 12 and 14, the paw withdrawal thresholds (WTs) of miR-rescue group was significantly higher than those of SNI + miR + Foxy5 group after miR-26a-5p rescue at the 9th day (*p < 0.05, **p < 0.01 compared with SNI + miR + Foxy5 group by Two-way ANOVA followed by Tukey post hoc test, n = 8 in each group). C At the days of 13 and 14, the paw withdrawal thresholds (WTs) of D12 rescue group was significantly higher than those of SNI + miR-26a-5p group (**p < 0.01 compared with SNI + miR-26a-5p group by Two-way ANOVA followed by Tukey post hoc test, n = 8 in each group)

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Journal of Neuroinflammation

ISSN: 1742-2094