Fig. 2

Microglial gene expression remodeling in plaques associated microglia. A Heatmap of differentially expressed genes in PAM (violets) versus CM (greens) along aging. The scaled expression value (row Z score) is shown in a blue–red color scheme with red indicating higher expression, and blue lower expression. The full data are available in Additional file 17: Table S5A. B Enrichment in DEGs in different gene signatures. The size and the color of each dot are, respectively, proportional to the number of DEGs and the adjusted p-value. The number of DEGs is also indicated in or at proximity of the dot. C, D Cytoscape representation of deregulated GO terms (“Biological Process” category) in the turquoise (C) and blue (D) gene modules. The full data are available in Additional file 17: Table S5B, C. Each dot represents a deregulated GO-Term; their size and color are, respectively, proportional to the number of genes in the GO-term and the enrichment adjusted p-value. GO-Terms are grouped into categories using the Autoannotate Cytoscape app. Insets: Boxplots of eigengene values for each sample in the respective modules (see also Additional file 4: Fig. S4)