Fig. 4

Galectin-3 deficiency delays light-induced retinal degeneration. A Representative SD-OCT scans and heat maps of retinal thickness from naïve and light-exposed WT and Lgals-3 KO mice at the indicated time points. Scale bar: 200 µm. B, C Quantification of the average thickness of the central retina (circle diameter 3 mm) (B) and peripheral retina (circle diameter 6 mm) (C). Data show mean ± SEM. Naïve n = 20; WT/Lgals-3 KO: 1d n = 15/19; 3d n = 18/20; 4d n = 19/20 eyes. ***P ≤ 0.001 by ordinary one-way ANOVA followed by Tukey’s multiple comparisons