Fig. 4

Blood brain barrier disruption and perivascular microglia recruitment was assessed on post-bleed day 3. A significant increase in luminal disruption was seen following SAH (p < 0.001) that was mitigated by IL-6 blockade (p < 0.01) (A). Perivascular microglia recruitment was observed as measured with IBA-1 and CD11b following SAH (p < 0.001) that was significantly reduced with IL-6 blockade (p < 0.001) (B). ZO-1 was significantly increased following SAH (C). Occludin was significantly increased following SAH (p < 0.001) but reduced with IL-6 blockade (p < 0.05) (D). * = significance compared to saline, ^#significance compared to SAH. White bar = 50 μm