Fig. 2

CSDS aggravates depressive-like behaviors via cGAS/STING pathway in the mouse model. A Enrichment GO analysis by cluster from Medscape database compared the susceptible mice with the control group. B Genes in the RIG-I-like receptor signaling pathway were up-regulated in CSDS susceptible group. C Protein level of cGAS, p-STING, TBK1 and IRF3 were detected in the control, susceptible, and resilient mice groups. Correlation analysis evaluated relevance between cGAS, p-STING, IRF3 and representations of behavior tests in tail suspension test (D), sucrose preference test (E) and forced swimming test (F). G Co-localization of GFAP/cGAS in the hippocampus of control, susceptible and resilient mice group. Red, GFAP; Green, cGAS; Blue, Hoechst. Scale bar, 50 μm