Fig. 2

Erbin alleviates SAE by attenuating neuronal damage, improving the synaptic structure, and increasing synaptic protein expression. A–C Neuronal damage of the hippocampal region was assessed by Nissl staining. Scale bar, 50 μm. D, E Image analysis of the thickness of PSD and the width of the synaptic cleft. F Synaptic structural changes were observed in TEM. Scale bar, 50 nm. SV, Synaptic vesicles; SC, Synaptic cleft; PSD, Postsynaptic density. G–J Levels of PSD95, SYP, and SYN1 in hippocampal tissue were measured by western blot. Data are representative of three independent experiments. *p < 0.05, **p < 0.01 vs. Sham group; ^#p < 0.05, ^##p < 0.01 vs. CLP group