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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease

Fig. 5

Aβ1–42 i.c.v inhibited cholinergic anti-inflammatory pathways and increased inflammation levels of colon. A–F Western blot and quantification of CHAT, CHRNA7, CD206, CD86, and NF-kb in colon of each group. G Immunofluorescence of CHAT in colon of each group. Scale bars, 100 μm. H–L Real-time PCR and quantification of inflammatory factor (TNF-α, IL-1β, IL-6, Arg-1, and IL-10) in colon of each group. n = 6 per group. Data were presented as mean ± SEM. Statistics were analyzed using one-way analysis of variance (ANOVA) and followed by Fisher’s least significant difference (LSD) test. ∗ P < 0.05, **P < 0.01, ns no statistical difference

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Journal of Neuroinflammation

ISSN: 1742-2094