Fig. 1
From: Alzheimer’s disease-related transcriptional sex differences in myeloid cells
Sex differences in the transcriptome of post-mortem microglial nuclei isolated from non-disease controls. A Box plots showing the enrichment of the Alzheimer’s disease GWAS signal (− log10P) between the F-MGN and M-MGN from previously published data sets [39, 41]. B, C Dot plots showing the enriched gene ontology (GO) biological processes in the upregulated sDEG in the B F-MGN (blue) and C M-MGN (red) isolated post-mortem from non-diseased brains. Significance of sDEG was determined via MAST analysis using an FDR < 0.05. The size of the dots corresponds to the size of the gene set, whereas the intensity of the colour denotes the FDR value of the overrepresentation of the corresponding biological pathway in the sDEGs. D Bar chart showing the enrichment of IR-AD gene sets. A negative log fold change (logFC) shows enrichments in the female nuclei whilst a positive logFC denotes enrichment in males