Fig. 5

Post-TBI administration of selective NHE1 inhibitor HOE642 in C57BL/6 wild-type mice accelerated neurological function recovery. a Experimental protocol. Either Veh (2.5% DMSO in PBS) or HOE642 (0.15 mg/kg) was administered twice per day from 1 to 7 days post-TBI in the C57BL/6J wild-type (WT) mice. b Survival rate of Veh or HOE-treated mice at 1–30 days post-TBI. c Adhesive contact and removal time of Veh and HOE-treated mice at 1–14 days after TBI. d Foot fault test of the same cohort of mice in C. e Y-maze test of the same cohort of mice in C at 30 days post-TBI. N = 7–11. Data are mean ± SEM. *p < 0.05, ****p < 0.0001, Veh. vs. HOE-treated groups