Fig. 5
From: SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain
Immune cell reduction in DRGs and spinal cord of SAFit2-treated mice 14 days after SNI. Mice underwent SNI surgery and were then treated with either vehicle or 10 mg/kg SAFit2 from day five to ten after the surgery. L4–L6 DRGs, spinal cord and sciatic nerve were collected from ipsilateral and contralateral sides at day 14 after the surgery. A Flow cytometry analysis was performed with tissue lysates to analyze the immune cell distribution after SAFit2 treatment. A–J Relative immune cell amount in L4–L6 DRGs and spinal cord. K–T Relative immune cell amount in sciatic nerves. The data represent the mean ± SEM from 5 mice per group. *p < 0.05, ***p < 0.001 two-way ANOVA with Sidak´s post hoc test for DRGs and SC figures, *p < 0.05 Student´s t-test with Welch´s correction for sciatic nerve figures. SNI spared nerve injury, DRGs dorsal root ganglia, SC spinal cord, SAFit2 selective antagonist of FKBP51 by induced fit 2, n.d. not detected