Fig. 1

The treatment of lymph nodes by PBMT attenuated cognitive deficits in APP/PS1 and 3xTg-AD mice. A The experimental procedure. B Representative swimming paths on day 5 during the acquisition phase. C The daily escape latency and the length of the path to the platform were recorded during training. D Representative swimming traces of six groups mice after the WMW test. E, F The number of crossing the platform of each group mice (E) and the percentage of time spent in target quadrant (F) of the original platform location during the 60 s of the MWM test. All data were detected by the MWM test. All quantifications are presented as mean ± SEM and were analyzed by one-way ANOVA test; ***p < 0.001 versus WT group, #p < 0.05, ##p < 0.01 versus indicated group (n = 6–8 mice per group)