Fig. 4

Hierarchical clustering and expression levels of the 89 differentially expressed genes in the TD group compared to the control. Fold change values were compared by Spearman correlation, average linkage and heatmap colors were normalized by the global Z-score. Among the genes differentially expressed in the contrast between TD and CT, genes related to inflammatory response (green), cell metabolism (blue), cell cycle, cell differentiation and survival (orange) and epigenetic regulation of neurogenesis (purple) were observed. CT controls, TD thiamine deficiency