Fig. 1

Trem2 expression is prominently increased in SC infiltrating BMDM during MHV–JHM CNS infection. A Trem2 and Tyrobp mRNA expression in brains and SCs from 5–6 mice at days 0, 5, 7, 10 and 14 pi after intracranial MHV–JHM infection. Data show the mean ± SEM from 2 independent experiments (n = 3–4 mice/timepoint/experiment) and are analyzed by unpaired two-tailed Student t test and two-way ANOVA analysis followed by Bonferroni test. ****p < 0.00001. B Normalized Trem2 and Tyrobp mRNA expression from Nanostring nCounter analysis of microglia and BMDM sorted from pooled SC of 5–7 mice at days 0, 5, 7, 10 and 14 pi from our previously published data (GSE214472) [22]