Fig. 5
Ly-6Chi cell content is an excellent biomarker to predict responsiveness to fingolimod in EAE mice. A ROC curve analysis showing that Ly-6Chi cell content presented the highest discriminatory ability for responder and non-responder EAE mice classified using the median of maximum clinical score, the % recovery or the residual score. B Cut-off value for the Ly-6Chicells/total blood cells to predict good responsiveness to fingolimod. C–F The level of Ly-6Chi cells could not discriminate between responder and non-responder EAE-FTY720 mice based on the median of the total accumulated clinical score (C, D) or the recovery index (E, F). AUC area under the curve (N = 18 mice)