Fig. 1

Genetic deletion of KLF11 aggravates long-term sensorimotor deficits in mice after TBI. Experimental TBI was induced in KLF11 KO and WT mice by unilateral controlled cortical impact, followed by a 30-d survival period. Long-term sensorimotor function was examined by the rotarod test, adhesive tape removal test, and foot fault test at the indicated time points (− 1, 3, 5, 7, 14, 21, and 28 days after operation). A The latency to fall in the rotarod test. B The time to touch and C time to remove the tape in the adhesive tape removal test. D The forepaw foot fault rate and E hindpaw foot fault rate in the foot fault test. Data are presented as mean ± SD, n = 11–12/group. Statistical analyses were performed by two-way ANOVA with Tukey’s post hoc test. *p < 0.05, **p < 0.01, and ***p < 0.001 versus TBI + WT group