|  | HC | AFF | NON | |||
---|---|---|---|---|---|---|---|
Median | (IQR) | Median | (IQR) | Median | (IQR) | ||
Growth factors | G-CSF | 6.3 | (2.22–12.92) | 13.95 | (5.255–29.02) | 10.43 | (2.603–13.95) |
GM-CSF | 16.96 | (8.22–21.53) | 19.46 | (9.02–30.77) | 18.5 | (12.65–32.69) | |
IL-7 | 12.81 | (4.23–21) | 19.04 | (8.415–28.79) | 18.04 | (6.81–23.61) | |
Innate inflammatory cytokines | TNF-α | 11.9 | (5.65–17.79) | 29.41*# | (9.778–82.13) | 10.89 | (5.28–26.76) |
TNF-β | 1.14 | (0.75–4.14) | 3.050 | (0.85–4.9) | 2.455 | (0.9–4.77) | |
IL-1α | 6.065 | (4.7–22.28) | 11.24 | (4.85–20.54) | 9.03 | (3.89–22.65) | |
IL-1β | 5.03 | (1.74–8.22) | 14.12*# | (4.798–30.63) | 5.33 | (2.86–14.89) | |
IL-6 | 45.95 | (23.6–94.35) | 102.7# | (55.69–632.4) | 63.51 | (31.24–135.2) | |
IL-15 | BLD | (–) | BLD | (–) | BLD | (–) | |
IFNα2 | 26.47 | (11.53–35.5) | 19.7 | (13.93–35.25) | 26.51 | (13.09–37.02) | |
Innate inflammatory chemokines | Eotaxin | 43.02 | (20.95–76.44) | 70.46 | (34.75–116) | 56.27 | (38.81–87.79) |
IL-8 | 10,401 | (3718–16,599) | 14,272 | (9378–18,994) | 10,897 | (8047–18,622) | |
IP-10 | 41.11 | (13.06–77.82) | 43.54 | (14.26–62.98) | 28.47 | (18.58–111.9) | |
MCP-1 | 10,124 | (3185–13,321) | 10,813 | (9638–13,560) | 9747 | (3991–13,005) | |
MIP-1β | 69.72 | (27.37–156.7) | 100.5 | (39.2–206.5) | 88.83 | (23.71–219.2) | |
TH1 cytokines | IFNγ | 10.16 | (6.87–16.02) | 25.64# | (9.373–45.39) | 11.86 | (7.65–26.45) |
IL-2 | 0.52 | (0.5–5.18) | 1.71 | (0.725–3.185) | 1.325 | (0.5–3.19) | |
IL-12p40 | 6.57 | (3.95–14.93) | 12.12 | (8.155–35.08) | 11.3 | (5.388–17.32) | |
IL-12p70 | 2.19 | (0.78–3.81) | 3.98 | (1.333–7.93) | 2.19 | (0.685–5.965) | |
TH2 cytokines | IL-4 | 2.62# | (2.25–5.923) | 5.3# | (3.33–15.13) | 4.955 | (2.598–7.585) |
IL-5 | BLD | ( -) | BLD | ( -) | BLD | ( -) | |
IL-13 | 2.4 | (0.6675–5.015) | 3.04 | (1.885–5.4) | 3.67 | (1.03–5.97) | |
TH17 cytokine | IL-17 | 1.615 | (0.425–5.158) | 3.865 | (1.47–6.898) | 2.78 | (1.505–5.975) |
Regulatory cytokines | IL-10 | 6.77 | (3.755–15.51) | 21.13 | (4.94–32.73) | 6.77 | (5.235–11.47) |
TGF-β | 1732 | (1040–2594) | 2235 | (1123–3029) | 2059 | (1304–2611) |