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Table 2 Concentration of cytokines/chemokines at baseline (media only)

From: Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder

  

HC

AFF

NON

Median

(IQR)

Median

(IQR)

Median

(IQR)

Growth factors

G-CSF

6.3

(2.22–12.92)

13.95

(5.255–29.02)

10.43

(2.603–13.95)

GM-CSF

16.96

(8.22–21.53)

19.46

(9.02–30.77)

18.5

(12.65–32.69)

IL-7

12.81

(4.23–21)

19.04

(8.415–28.79)

18.04

(6.81–23.61)

Innate inflammatory cytokines

TNF-α

11.9

(5.65–17.79)

29.41*#

(9.778–82.13)

10.89

(5.28–26.76)

TNF-β

1.14

(0.75–4.14)

3.050

(0.85–4.9)

2.455

(0.9–4.77)

IL-1α

6.065

(4.7–22.28)

11.24

(4.85–20.54)

9.03

(3.89–22.65)

IL-1β

5.03

(1.74–8.22)

14.12*#

(4.798–30.63)

5.33

(2.86–14.89)

IL-6

45.95

(23.6–94.35)

102.7#

(55.69–632.4)

63.51

(31.24–135.2)

IL-15

BLD

(–)

BLD

(–)

BLD

(–)

IFNα2

26.47

(11.53–35.5)

19.7

(13.93–35.25)

26.51

(13.09–37.02)

Innate inflammatory chemokines

Eotaxin

43.02

(20.95–76.44)

70.46

(34.75–116)

56.27

(38.81–87.79)

IL-8

10,401

(3718–16,599)

14,272

(9378–18,994)

10,897

(8047–18,622)

IP-10

41.11

(13.06–77.82)

43.54

(14.26–62.98)

28.47

(18.58–111.9)

MCP-1

10,124

(3185–13,321)

10,813

(9638–13,560)

9747

(3991–13,005)

MIP-1β

69.72

(27.37–156.7)

100.5

(39.2–206.5)

88.83

(23.71–219.2)

TH1 cytokines

IFNγ

10.16

(6.87–16.02)

25.64#

(9.373–45.39)

11.86

(7.65–26.45)

IL-2

0.52

(0.5–5.18)

1.71

(0.725–3.185)

1.325

(0.5–3.19)

IL-12p40

6.57

(3.95–14.93)

12.12

(8.155–35.08)

11.3

(5.388–17.32)

IL-12p70

2.19

(0.78–3.81)

3.98

(1.333–7.93)

2.19

(0.685–5.965)

TH2 cytokines

IL-4

2.62#

(2.25–5.923)

5.3#

(3.33–15.13)

4.955

(2.598–7.585)

IL-5

BLD

( -)

BLD

( -)

BLD

( -)

IL-13

2.4

(0.6675–5.015)

3.04

(1.885–5.4)

3.67

(1.03–5.97)

TH17 cytokine

IL-17

1.615

(0.425–5.158)

3.865

(1.47–6.898)

2.78

(1.505–5.975)

Regulatory cytokines

IL-10

6.77

(3.755–15.51)

21.13

(4.94–32.73)

6.77

(5.235–11.47)

TGF-β

1732

(1040–2594)

2235

(1123–3029)

2059

(1304–2611)

  1. BLD below the limit of detection
  2. #p value < 0.05 when comparing AFF with HC
  3. *p value < 0.05 when comparing AFF with NON
  4. †p value < 0.05 when comparing NON with HC