Fig. 2

APOE4 and female sex alter activation phenotype of near-plaque astrocytes. A Representative confocal images of THK-265-positive amyloid plaques (cyan) and individual GFAP-immunoreactive astrocytes (pseudo-colored orange–purple). Scale bars = 10 μm. Quantification of B astrocyte primary process number, and C astrocyte soma area in male (E3M) and female (E3F) E3FAD and male (E4M) and female (E4F) EFAD mice. Data are presented as box (mean and 25th and 75th quartiles) and whisker (minimum and maximum values) plots from n = 6/group of mice at age 6 months. *p < 0.05, **p < 0.01