Fig. 3

Machine Learning and Bayesian Network confirm IL-17A as central cytokine in HAM/TSP disease status. A Machine learning-derived decision tree discriminating AS from HAM/TSP patients (J48 pruned tree) with 90% accuracy (97 out of 110 PLHTLV-1 correctly classified, of which 61/67 AS and 38/43 HAM/TSP patients, ROC AUC 0.87, Kappa statistic 0.79). B Bayesian Network representing the strongest associations between cytokines, GlycA, clinical and demographic data (strength of arcs as defined previously [19]: dark blue 100×, light blue 10×). Proviral load was not significantly associated with the other parameters and hence not shown