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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic neuropathic pain in mice

Fig. 5

TET2 regulated the TXNIP/NLRP3 expression in STZ-diabetic mice DRG. A–C Intrathecal injection of TET2-siRNA and the mRNA expression of TET2 (A), Txnip (B), and NLRP3 (C) in DRG were examined. n = 4–5, *p < 0.05 versus DNP + Scr-siRNA group, #p < 0.05 versus DNP + vehicle group, n.s., not significant, one-way ANOVA with Tukey’s post hoc test. D Representative Western blot bands for TET2 and α-tubulin in the DNP group after the intrathecal injection. E Statistical analysis of TET2 and α-tubulin. n = 6, *p < 0.05 versus DNP + Scr-siRNA group, ##p < 0.01 versus DNP + vehicle group, one-way ANOVA with Tukey’s post hoc test. F Representative Western blot bands for NLRP3 and α-tubulin in different groups. G Statistical analysis of NLRP3 and α-tubulin. n = 8. *p < 0.05 versus DNP + Scr-siRNA, #p < 0.05 versus DNP + vehicle group, one-way ANOVA with Tukey’s post hoc test. H Intrathecal injection of TET2 significantly relieved mechanical allodynia in DNP group. n = 10–11. ***p < 0.001 versus DNP + Scr-siRNA, ###p < 0.001 versus DNP + Vehicle, two-way ANOVA with Bonferroni post hoc test. Experiments were repeated at least 3 times independently

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Journal of Neuroinflammation

ISSN: 1742-2094