Fig. 7
From: Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway
H2 protects against plantar incision-induced postoperative pain by upregulating the Trx1/ASK1/MMP-9 signaling pathway. Plantar incision surgery increases ASK1/JNK/p38 phosphorylation mediated microglia activation, enhances MMP-9 activity and IL-1β cleavage, and subsequently induces neuroinflammation, which contributes to the progression of postoperative pain in mice. Inhalation of H2 and administration of HRS, which increases Trx1 expression, could ameliorate postoperative pain