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Fig.3 | Journal of Neuroinflammation

Fig.3

From: Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism

Fig.3

FMT and SCFAs treatment increase CCH-induced metabolite SCFAs. A Analysis of fecal SCFAs concentration by gas chromatography-mass spectrometry (GC-MS) (n = 8 in sham, BCCAo and BCCAo + FMT group; n = 6 in BCCAo + SCFAs group). B Analysis of colonic SCFAs concentration by GC-MS (n = 5 per group). C, D Segregation trends of fecal and colonic SCFAs evaluated by orthogonal partial least squares discriminant analysis (OPLS-DA) respectively. E, F Spearman correlation analysis between gut microbiota and metabolite SCFAs using fecal samples. Data are expressed as mean ± SD. *P < 0.05 vs. sham group. #P < 0.05 vs. BCCAo group. In E, F, *P < 0.05, **P < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094