Fig. 1
From: Teriflunomide as a therapeutic means for myelin repair
Cuprizone (CPZ) mediated demyelination and teriflunomide treatment. A Rostro-caudal directed coronal brain slices were collected between − 1.94 and − 2.34 mm Bregma. B Timeline of (C–C′′) CPZ induced demyelination and of teriflunomide treatment in adult (8 weeks) mice. CPZ treatment lasted for 6 weeks. Teriflunomide was applied orally by means of two different application schemes: (1) early pulse during the fourth week of cuprizone challenge for 7 consecutive days (pulse) or (2) continuously for the final 20 days of cuprizone treatment (constant). Mice were sacrificed after 7 days of remyelination