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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis

Fig. 3

Effect of Abcc8 knockout (KO) on axial diffusivity (AD) in brain after cecal ligation and puncture (CLP) in mice, as assessed by magnetic resonance imaging (MRI). On day 1 (A) and day 4 (B) after CLP, wild-type (WT) and Abcc8 KO mice underwent brain MRI (WT CLP (WCLP), KO CLP (KCLP)). Additional controls included shams (WT SHAM (WS), KO SHAM (KS)). Regions of interest (ROI) analysis was performed after manual delineation of a priori regions of the brain that include the cortex, hippocampus, and thalamus. Mean AD scalars are shown. Each graph represents the mean AD value from a specific ROI. (*P < 0.05 vs. WS; # P < 0.05 vs. KCLP) P values were calculated by ANOVA, and error bars represent SEM) (sham n = 5, and CLP n = 10 for each timepoint)

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Journal of Neuroinflammation

ISSN: 1742-2094