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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis

Fig. 5

Behavioral outcomes after cecal ligation and puncture (CLP), in wild-type (WT) and Abcc8 knockout (KO) mice as assessed by (A) beam balance test (B) spatial memory acquisition in the Morris water maze (MWM) paradigm and (C) probe trail. A Abcc8 KO mice exhibit a nonsignificant decrease in latency on the beam balance task on day 1 post-CLP and improved on days 2–5 after CLP (P > 0.05). B WT mice demonstrated significant impairment in learning on the MWM 7–8 day post-CLP (#P < 0.05 vs. KCLP). A visible platform task was performed on days 12–13 post-CLP. C Probe trial was performed on days 12–13 post-CLP and % time in target quadrant was comparable in all groups (sham n = 6, and CLP n = 8/genotype)

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Journal of Neuroinflammation

ISSN: 1742-2094