Fig. 1

CUMS affects weight gain and depression-like behavior in both female and male mice. a Experimental design diagram. b Changes in body weight of mice. c Changes in blood sugar. d Content of 5-HT in hippocampus. e Road map of the open field experiment. f Ratio of distance between center and periphery. g Length of the total journey. h Center to peripheral delay time. i Path map of the morris water maze. j Escape latency. k Number of platform crossings. l Distance traveled in the correct quadrant. m Sugar water preference. n Forced to swim immobile time. o Tail suspension experiment immobility time. Each value represents the mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 means difference of female vs. male mice at the same point