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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress

Fig. 4

MgH2 treatment improves depressive-like behaviors induced by 24-h restraint. A Model of 24-h-restraint stress. B Schematic diagram displaying the behavioral testing in 4 different groups to test the effect of MgH2 treatment. C OFT, statistical analysis of total distance (F = 0.7394), time (F = 0.1454) and entries (F = 0.342) in the central area, n = 6 mice per group. D MBT, statistical analysis of the number of buried marbles (F = 0.0601), n = 6 mice per group. E Light/dark transition test (LDT), statistical analysis of time in the light chamber (F = 0.1163) and transition numbers (F = 0.3597), n = 6 mice per group. F SPT, statistical analysis of the percentage of sucrose consumption (F = 7.616), n = 6 mice per group. G TST, statistical analysis of immobile time (F = 4.1247), n = 6 mice per group. H Forced swimming test (FST), statistical analysis of immobile time (F = 7.9412), n = 6 mice per group. Data are presented as mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094