Fig. 2

TNEA promotes the degradation of NLRP3 inflammasome components in the hippocampi of 5xFAD mice. A Representative Western blots showed the levels of NLRP3, CASP1, and IL1B in the HI of mice from each group. B Data are quantified as mean ± SEM (male, n = 6). **p < 0.01 vs. 5xFAD group analyzed by unpaired t-test or unpaired t test with Welch's correction. C Representative Western blots showed the levels of ASC in the HI of mice from each group. D Data are quantified as mean ± SEM (male, n = 3). *p < 0.05 vs. 5xFAD group analyzed by one-way ANOVA. E Representative Western blots showed the levels of p-RELA (p65) and RELA (p65) in the HI of mice from each group. F Data are quantified as mean ± SEM (male, n = 6). ns vs. 5xFAD group analyzed by unpaired t-test. G Representative Western blots showed the levels of pro-IL1B and cleaved IL1B expression in the HI of mice from each group. H Data are quantified as mean ± SEM (male, n = 5–7). *p < 0.05, ns vs. 5xFAD group analyzed by unpaired t-test