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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation

Fig. 3

Effects of TNEA on NLRP3–ASC complex in the hippocampi of 5xFAD mice. A Representative immunohistochemical (IHC) staining images of NLRP3 (red), ASC (green), nuclei (Hoechst, blue) and their colocalization in the hippocampal CA3 of mice from each group. Scale bar: 100 μm. 4× magnified images were shown for the selected area. Negative controls are shown in Additional file 1: Fig. S3. B Images were processed using ImageJ to quantify the average area of NLRP3, ASC and their colocalization (divided by the area of Hoechst). Data are quantified as mean ± SEM (male, n = 4–6) and analyzed by one-way ANOVA. **p < 0.01, ***p < 0.001 vs. 5xFAD group

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Journal of Neuroinflammation

ISSN: 1742-2094