Fig. 5

TNEA promotes the autophagic degradation of NLRP3 inflammasome components depending on TFEB. A Representative Western blots showed the levels of TFEB, NLRP3, CASP1 and IL1B in the hippocampus of mice from each group with/without Tfeb knockdown (KD). B–G Data are quantified as mean ± SEM (male, n = 4). *p < 0.05, **p < 0.01, ***p < 0.001, ns (p > 0.05) vs. TNEA⁺-TFEB-KD⁺ group, analyzed by unpaired t test (TFEB-KD⁺ vs. TFEB-KD⁻) and one-way ANOVA