Fig. 9
From: Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization
Inhibiting ACAT1 reduces mRNA for ACAT1 and associated inflammatory mediators in OIR retinas. OIR mice were treated with the ACAT1 inhibitor K604 or vehicle from P7 to P16. Retinas were enucleated at P17 and gene expression was analyzed by RT-PCR. a–g Analysis of mRNA levels shows upregulation of a ACAT1, b TREM1, c MCSF, and d DAP12, along with the inflammatory markers e IL1β, f TNFα, and g IL6 in OIR retinas, compared to RA control. K604 treatment significantly reduced their expression as compared to vehicle treated OIR-retinas. mean ± SEM, n = 4